Decaflon

@ Home 3 most used applications
1- Firefox
2- Apple mail
3- Adiumx

+5
1- VLC
2- Itunes
3- Transmition
4- Xpad
5- Iphoto

@ Work 3 most used
1- Apple mail
2- Illustrator
3- Indesign

Mail, Safari, Adium — Quicksilver, Photoshop, Terminal, Vienna, TextEdit

sorry guys.. i just missed that this is for apple only and I am on PC

sorry guys.. plz leaders Mike delete this post

Here goes...
SkEdit, Transmit, Style Master, I-tunes ,Firefox

iTunes+Firefox+mail

Bon Echo (optimized fork of Firefox)
Newsfire
iTunes
+
Yojimbo
Adium
Mail + SpamSieve
XTorrent
Word (I don't know why I don't use Pages more)

Background apps:
Yahoo! Widget Engine
iClip (still using the beta of version 4 cause I'm cheap)
HighPriority
Menu Meters
MenuCalendarClock
Overflow
Witch
CornerClick
Google Notifier

Bon Echo isn't a fork, mate... It was the codename for FF2.0 before it hit alpha1... There are optimised builds but if yours has Bon Echo plastered all over it, it's an ancient version =)

You should be able to find a newer optimised nightly somewhere.

Safari, Mail, NewsFire, TextMate, Transmit.

Adium + Aperture + iTunes + Safari + Twitterific

Firefox, iTunes, Photoshop, TextMate, Adium.

Mine would be Firefox, MSN Messenger, Entourage, iTunes and Cyberduck

Bon Echo isn't a fork, mate... It was the codename for FF2.0 before it hit alpha1... There are optimised builds but if yours has Bon Echo plastered all over it, it's an ancient version =)

You should be able to find a newer optimised nightly somewhere.

Hmm...I'm running 2.0.0.2, which is also the version listed on the front page of Mozilla.com. It also uses the 'Aqua' form widgets instead of the standard Firefox ones. And anytime there's an update to Firefox there's an update for my browser shortly afterwards. In any event, It sure doesn't seem like alpha software.

In no particular order:

Firefox
SciTE w/ snippets
Amarok
Gimp
Gaim
gFTP

Safari, Mail, iChat, iTunes, Transmission

iTunes
Camino
AdiumX

+

Textwrangler
CSSEdit
Photoshop
Safari
Dashboard

Camino
Mail
Vienna
+
Adium
iTunes
Textmate
Quicksilver
Photoshop

firefox, textmate, and fetch

Firefox
Adium
iTunes

Firefox
iTunes
Photoshop

Top 3: Mail, Firefox, Quicksilver
+5: NNW Lite, iPhoto, Colloquy, Adium, YummySoup!

textmate, photoshop, transmit
mail, firefox, adium,
google reader, wordpress, flickr
firefox, google, cj

Firefox, Dreamweaver, Windows Media Player

Windows: Firefox, Photoshop, putty, mIRC, iTunes

Mac: Firefox, Terminal, irssi, Photoshop, World of Warcraft

My Windows machine is going on four years old, the VGA slot decided to started malfunctioning so I am running off my on board card which limits a lot of things. That's all changing in a month as I am working to build a new system :)

Edit: @ Rich: Who needs a virus scanner and anti-spyware when you run Firefox and can identify viruses and take care of them without flinching, right? ^_^

Firefox
TextMate
Mail

+

CSSEdit
NetNewsWire
Photoshop
Cha-Ching
iTunes

Terminal
Camino
Mail
+
Gimp
Inkscape
Neooffice
Cyberduck
Smultron

Optimized Firefox
Mail
iTunes

+

iChat
GIMP
Open Office
Safari
Moody

I'll post my Windows and Linux apps:

Windows:
Firefox (which handles email, IM [meebo], and music [Pandora])
XChat (IRC)
Notepad++ (text editing)

I don't use much more than that. Occasionally I get hooked on a game (like Sauerbraten or AssaultCube - both free games), and I play it constantly for two days and then forget about it. I'm not including any of those on this list.

Linux:
Firefox
XChat
Gedit
The GIMP
GAIM (meebo is sometimes messed up in Firefox)

I need a Mac

A lot of my apps have already been mentioned, so I won't repeat unnecessarily, but:

1. Coda
2. XAMPP for Mac
3. Play